Synthetic virus-like particles target dendritic cell lipid rafts for rapid endocytosis primarily but not exclusively by macropinocytosis.
DC employ several endocytic routes for processing antigens, driving forward adaptive immunity.Recent advances in synthetic biology have created small (20-30 nm) virus-like particles based on lipopeptides containing a Pet Hair Clippers virus-derived coiled coil sequence coupled to synthetic B- and T-cell epitope mimetics.These self-assembling SVLP e